Eur J Cancer Prev. 2012 Sep;21(5):453-9.
Inverse association between yoghurt intake and upper aerodigestive tract cancer risk in a Japanese population.
Kawakita D, Sato F, Hosono S, Ito H, Oze I, Watanabe M, Hanai N, Hatooka S, Hasegawa Y, Shinoda M, Tajima K, Murakami S, Tanaka H, Matsuo K.
Source
Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan.
Abstract
Although the combination of tobacco smoking and alcohol drinking account for
approximately 80% of upper aerodigestive tract (UADT) cancer risk, the role of
dietary factors, including dairy products, in the risk of these cancers remains
controversial. We aimed to evaluate the association between dairy product intake
and UADT cancer risk in a Japanese population. We conducted a case-control study
in 959 patients with UADT cancer and 2877 sex- and age-matched noncancer control
subjects who visited the Aichi Cancer Center in Nagoya, Japan. Data on lifestyle
factors, including diet, were obtained by self-administered questionnaire.
Associations were assessed by multivariate logistic regression models that
considered potential confounders. We found a significant inverse association
between yoghurt intake and UADT cancer risk with multivariate-adjusted odds
ratios and 95% confidence intervals for <1 time/week, >= 1 time/week and <1 time/day,
and >= 1 time/day consumption of yoghurt of 0.70 (95% confidence interval:
0.54-0.91), 0.67 (0.54-0.84), and 0.73 (0.55-0.95) relative to nonconsumers (P
trend=0.005). When stratified by primary tumor site, this association was
significant among patients with hypopharyngeal, laryngeal, and esophageal cancer.
However, we saw no significant association between milk or butter intake and
UADT cancer risk. In this study, we found that a high intake of yoghurt may
lower the risk of developing UADT cancer in a Japanese population. Further
investigation of this association is warranted.
PMID: 22179690 [PubMed - indexed for MEDLINE]