Int J Cancer. 2015 Oct 15;137(8):1953-66.
Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC).
Wozniak MB1, Brennan P1, Brenner DR1,2, Overvad K3, Olsen A4, Tjønneland A4, Boutron-Ruault MC5,6, Clavel-Chapelon F5,6, Fagherazzi G5,6, Katzke V7, Kühn T7, Boeing H8, Bergmann MM8, Steffen A8, Naska A9,10, Trichopoulou A9,10,11, Trichopoulos D10,11,12, Saieva C13, Grioni S14, Panico S15, Tumino R16, Vineis P17,18, Bueno-de-Mesquita HB19,20,21,22, Peeters PH23,24, Hjartåker A25, Weiderpass E26,27,28,29, Arriola L30, Molina-Montes E31,32, Duell EJ33, Santiuste C34, Alonso de la Torre R35, Barricarte Gurrea A36,37, Stocks T38,39, Johansson M1,39, Ljungberg B39, Wareham N40, Khaw KT41, Travis RC42, Cross AJ17, Murphy N17, Riboli E17, Scelo G1.
Abstract
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment versus the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
© 2015 UICC.
PMID: 25866035 [PubMed - indexed for MEDLINE]